日誌
孔鏘的絕症、睡眠呼吸中止症怎麼治總整理Part-IV(應該還是跟副交感神經表達過低有關) ...
導讀：
孔鏘的絕症、睡眠呼吸中止症怎麼治總整理Part-III(建議善存+維他命C+多喝豆漿、茶)
告訴我們：
小兒阻塞性睡眠呼吸暫停患者
細胞因子譜顯示明顯缺乏IL-4和IL-2。
~~~
腸躁症治療總整理Part-II(IL-2應該也有正面幫助，建議善存+500毫克維他命C+豆漿、茶)
告訴我們：
IL-4和IL-10和興奮副交感神經有關
白細胞介素-2(IL-2)增強交感神經
交感神經元對IL-2的反應是濃度依賴性的
~~~
Obstructive sleep apnea (OSA) is associated with sympathetic overactivity.
阻塞性睡眠呼吸暫停（OSA）與交感神經過度活動有關。
~~~
Therefore, parasympathetic autonomic function impair in obstructive sleep apnea
syndrome (OSAS) .
因此，副交感神經自主神經功能在阻塞性睡眠呼吸暫停綜合症（OSAS）中受損。
During sleep, sympathetic neural activity decreases in association with an increase
in parasympathetic activation.
在睡眠期間，交感神經活動減少與副交感神經激活的增加有關。
More than 30 years ago deBurg Daly et al 19 showed that hypoxaemia resulted
in tachycardia in spontaneously breathing anaesthetised animals
30年前，deBurg Daly等人19表明，低氧血症導致自發呼吸麻醉的動物發生心動過速
Sympathetic excitation and apnoea
交感神經興奮和呼吸暫停
They found a striking relationship between apnoea, oxyhaemoglobin desaturation,
surges in interarterial pressure, and sympathetic activation (fig4).
他們發現呼吸暫停，氧合血紅蛋白飽和度降低，動脈壓增高和交感神經激活之間存在顯著關係（圖4）。
The hallmark of sleep apnea is recurrent episodes of hypoxemia and arousals
throughout the night.
睡眠呼吸暫停的特點是整個晚上反複出現低氧血症和喚醒。
Obstructive sleep apnea (OSA)
阻塞性睡眠呼吸暫停（OSA）
Patients with OSA showed significantly reduced values of vascular strain of
common carotid arteries.
OSA患者顯示出頸總動脈血管張力明顯降低。
Patients with OSA show significantly reduced vascular strain assessed by ultrasound-based
speckle-tracking. Vascular stiffness increases with the severity of the disease.
OSA患者顯示血管張力顯著降低。血管僵硬程度隨疾病的嚴重程度而增加。
Aortic stiffness is highest in subjects with the lowest parasympathetic activity.
在副交感神經活動最低的受試者中，主動脈僵硬度最高。
Schematic drawing summarizing the potential associations of sympathetic overdrive
with arterial stiffness in the chronic and acute setting leading to increased
cardiovascular risk.
示意圖概述了在慢性和急性環境中，交感神經過速與動脈僵硬的潛在關聯，導致心血管風險增加。
儘管
Vascular smooth muscle is primarily innervated by the sympathetic nervous system.
Alpha-1 and alpha-2 receptors function to cause vasoconstriction by contracting vascular
smooth muscle cells leading to systemic hypertension.
血管平滑肌主要受交感神經系統神經支配。 Alpha-1和Alpha-2受體引起血管收縮(血管張力)功能通過收縮血管平滑肌細胞導致全身性高血壓。
小結1：
所以睡眠呼吸暫停似乎與交感神經過度表達、副交感神經表達過低有關。
Etiology. Sleep apnea occurs when there is not enough space to accommodate sufficient airflow in a portion of the upper airway during sleep. When muscle tone is decreased,the result is a repetitive total or partial collapse of the airway.
病因學。當睡眠期間上呼吸道的一部分空間不足以容納足夠的氣流時，就會發生睡眠呼吸暫停。
當肌肉張力降低時，結果是氣道反復全部或部分塌陷。
Obstructive sleep apnea (OSA) is a highly prevalent disease characterized by recurrent episodes of upper airway obstruction that result in recurrent arousals and episodic oxyhemoglobin desaturations during sleep.
阻塞性睡眠呼吸暫停（OSA）是一種高度流行的疾病，其特徵在於上呼吸道阻塞的反複發作，
導致發作時反復引起喚醒和陣發性氧合血紅蛋白飽和度下降。
Upper airway obstruction is common during both anaesthesia and sleep.
Obstruction is caused by loss of muscle tone present in the awake state.
The velopharynx, a particularly narrow segment, is especially predisposed
to obstruction in both states.
在麻醉和睡眠期間上呼吸道阻塞是常見的。阻塞是由清醒狀態下出現的肌張力下降引起的。
舌咽是一個特別狹窄的部分，在兩種狀態下都特別容易阻塞。
Bronchoconstriction occurs due to contraction of bronchial smooth muscle in response to parasympathetic stimulation.
支氣管收縮是由於副交感神經刺激引起的支氣管平滑肌收縮(收縮產生張力)而發生的。
Airway smooth muscle is innervated by sympathetic and parasympathetic nerves.
When activated, airway nerves can markedly constrict bronchi either in vivo or in vitro,or can completely dilate a precontracted airway.
氣道平滑肌由交感神經和副交感神經支配。激活後，氣道神經可以在體內或體外顯著收縮支氣管，或者可以完全擴張預收縮的氣道。
The predominant contractile innervation of airway smooth muscle is parasympathetic
and cholinergic in nature
氣道平滑肌的主要收縮神經支配本質上是副交感神經和膽鹼能
Obstructive sleep apnoea (OSA)
阻塞性睡眠呼吸暫停（OSA）
OSA causes severe symptoms, such as excessive daytime somnolence, and is associated
with a significant cardiovascular morbidity and mortality.
OSA會引起嚴重的症狀，例如白天過度嗜睡，並與明顯的心血管疾病發病率和死亡率相關。
鬼壓床是怎麼回事？怎麼預防？(發生時建議調節呼吸，平時建議善存+多喝豆漿+濃茶)
告訴我們：
白介素4（IL-4），IL-10抑制睡眠。(由導讀可知和副交感神經有關)
想睡覺需要IL-2及IFN-r
接近發作性睡病發作時，發現干擾素-γ(IFN-r)的水平升高。
發作性睡病患者的T細胞顯示促炎細胞因子IL-2的產生增加。
小結2：
所以睡眠呼吸暫停似乎與交感神經過度表達、副交感神經表達過低有關。
糖尿病或降血糖不用去管低升糖指數、高升糖指數食物，降血壓也是一樣的東西~~~
告訴我們：
IL-4和IL-10和興奮副交感神經有關
能提高IL-4的元素：
鎂、鋅、維生素A、維生素C、兒茶素、茄紅素、薑黃素、黃酮類化合物(
生物類黃酮、大豆異黃酮)、鞣花酸
能提高IL-10的元素：
鎂、鋅、錳、硒、維生素A、維生素D、維生素E、兒茶素、薑黃素、碘、茄紅素
、黃酮類化合物(生物類黃酮、大豆異黃酮)、鞣花酸
總結以上：
建議提高副交感神經表達治療睡眠呼吸中止症
提升IL-4+IL-10建議一天一粒男性/女性善存
+一天兩瓶高兒茶素每朝健康綠茶或茶裏王濃韻(https://yingyang.911cha.com/OWY2.html)
